The FBH serious high contained granulation suit is integrated high shear mixer, cone mill (wet & dry), FBD into isolator with reliable sealing. The weighed material inside the contained container is transferred from weighing & dispensing isolator into the granulation suit, and loading through the high contained handling unit, e.g RTP, αβ Valve, LEV, etc, into the high shear mixer (or integrated with wet mill) for wet granulation, FBD drying (or integrated with dry mill) and unloading the high contained handling unit, e.g αβ valve, quick liner, etc, into the high contained container. The whole granulation processing is working under the isolation sys with reliable AHU isolator handing unit. The take in air of isolator is cleaned from the H14 grade push-push filter with recycling loop ensure the safe and ensured negative pressure condition. According to specific project features, the high contained granulation could reach to OEB 3 to OEB 5 level.